response 355 of 475:

Mar 19 22:36 UTC 2004

No. The Ainu were driven north to Hokkaido.  The Ryukyuans are different.

response 357 of 475:

Mar 24 17:34 UTC 2004

keesan may wish to check out page D1 of today's WSJ regarding cancer 
survivorship.

response 359 of 475:

Mar 25 21:00 UTC 2004

re:  "#358 (keesan):   (1) I don't have WSJ - is it online?  Would you 
summarize please?

(2)  It is now 2 months since my Jan 26 chemotherapy.  I read that it 
takes 2-3 months or up to a year to recover from chemotherapy.

(3)  Jim was reading in a library magazine that the single biggest 
problem for women with breast cancer is that their hair falls out 
during treatment."

(1)  If one has a subscription.  You ought to read it yourself.  The 
library certainly has it.

(2)  That would be a *minimum* estimate!

(3)  Depending on whether the treatment was surgical, chemical, or 
radiation.

response 361 of 475:

Mar 27 23:26 UTC 2004

(1)  If recovery is defined as 100% pre-cancer level, then it is still 
progressing.

(2)  Can't say what symptoms disappeared first because it was almost 2 
years ago and am not into record-keeping in that regard.

response 363 of 475:

Mar 28 21:34 UTC 2004

Actually, recollections are rather muddled.  Muscles aren't week.  
Evening tiredness & weakened memory.  Suggest you refer to WSJ article 
for where to get more info.

Radiation treatments began 3.5 wks after chemo stopped and went for 
4.5 wks.  Then, 1 wk later, father in law died.  Two mnths later, I 
was in a head-on crash & totalled a car.  1.5 mos. later, father 
entered hospice and died a mo after that.  Had a lot of distractions, 
wouldn't you agree? 

response 365 of 475:

Mar 29 22:35 UTC 2004

I just read a study of diffuse large cell lymphoma and they give various
statistics.  For high-grade DLCL 61% experience 'complete remission'.  Of the
high-risk category (which I think I was in) 44% have CR and 26% survive five
years.  Since I had CR (no nodes remain enlarged) my 5-year survival is
greater, about 60% (divide 26 by .44).   Risk factors include being over 65
and having an advanced stage of the disease (which I did by all measures).

Of those who have CRs, in other studies, 20-50% will have relapses, which
means I have at least a 50% chance of being permanently 'cured'.  
Of those with relapses, the same therapy will produce another remission in
20-35% but only for about a year or so.  A stronger therapy involving removal
of your own bone marrow stem cells, treatment with chemicals that destroy
these cells, and transplanting of your own cells, gives 53% of the relapsed
patients who were originally cured a 53% chance of surviving 5 more years.
So I figure I have a 75% chance of being around for quite a while, or higher.
The Rituxan treatment increases the odds somewhat.  

I will try not to think about this a lot, but my odds are pretty good compared
to a lot of other people with other types of cancer. 

Lymphoma can be caused by various viral infections, including herpes.  I have
a cold sore once in a while.  A book on oxygen says that half of people with
cold sores (herpes simplex) are likely to develop the oxidized protein plaques
which cause Alzheimber's disease in old age.  I will be happy to achieve old
age despite this risk.

Back to my translation on oncogenes, which produce certain protein products
that can be used in the diagnosis of different types of cancer and of the
stage to which it has progressed.

response 367 of 475:

Mar 29 23:22 UTC 2004

I don't understand your question.  Viral infections can cause lymphoma.  This
might be because the body creates a lot of free radicals when fighting off
the infection, and the free radicals can damage DNA.  Maybe it is because
lymph cells participate in fighting infections and multiply more during an
infection so have more chances of mutating.  Maybe some viruses actually get
into the cell and insert copies of themselves into the DNA randomly thereby
causing mutations.  The website did not go into this.  Sun has similar effect
to infections, in producing free radicals, which is why overexposure to the
sun makes you feel like you have the flu.

response 369 of 475:

Mar 30 03:26 UTC 2004

I doubt that anyone knows.  There are still a lot of mysteries, the human body
being a major one.  People are constantly developing cancer, except most of
the time the body manages to kill the cancer cells.  People with poor immune
systems, such as people with HIV or those taking immunosuppressants after
transplants, are much more likely to not keep the cancer from getting out of
control.  Sometimes if you have one infection, your body is busy fighting that
and other infections, or cancers, can get out of control.  

Chemicals can also cause cancer, as can X-rays - anything that damages DNA.

response 371 of 475:

Apr 1 02:26 UTC 2004

I just read that 1/3 of cancers worldwide are caused by infections.  The
immune system generates a lot of dangerous chemicals to fight off the
invaders, which can also damage the body itself.  Since the lymph cells are
part of the immune system, they are exposed to these chemicals and can have
their DNA damaged.  The compounds in tobacco smoke also damage DNA to the
point where smokers can have up to 50% more of these products of broken DNA
in their urine.  I wonder if smokers are more likely to get gout, since the
uric acid that causes it is a breakdown product of DNA.  People with gout are
supposed to avoid foods with rapidly dividing cells such as asparagus and
mushrooms, because they have more DNA in them (nucleic acids).  

Free radicals are also what causes aging.  Ultraviolet light causes your skin
to age faster and get wrinkled, as does smoking.

response 373 of 475:

Apr 8 09:31 UTC 2004

It is now a little over 2 months since my last chemotherapy (Jan 26) and the
side effects are mostly still with me - slight pain in the spleen area where
the tumor was, and in my hand where I had a lot of IVs.  Bleeding during
defecation continues (probably due to my intestinal lining not being recovered
yet - and I still have a somewhat sore tongue and runny eyes and nose) but
the pain has mostly stopped as of a month ago.  Hot flashes down to about once
every 2 hours instead of 45 minutes.  I am sleeping better, on average.
It still hurts to sit, and where I rest my hands to type, but a couple of days
ago it started hurting less to sit, so yesterday we walked to my apartment.
Jim is fixing the washing machine there so that I can move back once it gets
a bit warmer.  I cleaned up some (he rearranged things when  friend stayed
there and I found my pots and pans on the basement floor) and recycled a lot
of papers that were relevant last time I lived there in July.  And we put air
in my bike tires and I was going to walk it back, but I decided to try riding
and discovered my biking muscles are still in better shape than my walking
muscles, so I biked all the way back (which is mostly downhill).  First time
since July I have been on a bike and now I am no longer limited to a 2 mile
radius.  Hurray!

        Food is tasting closer to normal but I am still not gaining any more
weight - 114 after supper with clothing on.  My saliva is not as sticky as
a couple of weeks ago.  Things are gradually returning to a balance.

        My yard could use weeding, but it may not happen for a while.  I still
have trouble getting up after I get down.  There will probably be no garden
this year, and I don't expect to be strong enough to go on vacation or even
swimming (2 hours by bike) but it will be really nice to be able to get to
the river and local parks again.  

        Next checkup (CAT scan) May 18.  

response 375 of 475:

Apr 17 02:00 UTC 2004

Two months since the PET scan, almost 3 months since the last chemotherapy.
Supposedly it takes at least 2-3 months to feel normal.  This week has been
somewhat of a watershed.  I can bike again (or I could until Jim started to
move all the parts from my frame to one that is less worn out).  So I am back
to walking, and today we went through Eberwhite Woods, which is full of
patches of yellow trout lily and some small white flowers which I think are
Spring Beauty (claytonia) or anemonella.  Two days ago we biked to Dolph Woods
and saw bloodroot (large white flowers) and just-emerging mayapple leaves,
like folded umbrellas.  
        Today's trip was to bring a carton full of Chinese restaurant take-out
boxes to the local Chinese restaurant to trade for two spring rolls.  They
decided to give us two free soups in addition.  We walked back via another
woods near I-94, where there is a pond full of calling frogs (difficult to
hear over the highway racket) that might be chorus frogs.  We startled a
garter snake.  The easements next to Maple Road are carpeted with purple
violets that you can sometimes smell over the highway fumes, and a few white
ones.  We stopped at the Chinese food store for vegetables.  The guy at the
register knew the numbers in English (4, 3) so I showed off my numbers in
Chinese and he gave us some Chinese peanuts and I said 'thanks' and 'goodbye'
which he repeated properly.  
        I trudged back.  One mile still wears me out, but my muscles look they
are back.  I am up to 115 pounds after supper, which is probably about what
I was before I got sick last year January (112 before breakfast then).  I
wonder where it has gone as I can't see any body fat and I am still short on
muscle.
        This week's big progress is that my voice seems to be back.  It was
not quite back on Sunday and I was starting to think it might stay weak.
        I am still hoping it won't always hurt to sit and that my digestion
will eventually recover and my fingertips stop feeling numb, but these are
not serious problems.  Still sore in the area over where my spleen probably
got enlarged to, nobody knows why.  Scar tissue?  I am going to try to do the
Huron River canoe cleanup tomorrow. We might skip the mattresses this year.
And I might just snag things with a pole instead of climbing onto the bow and
leaning over.  With luck there will be turtles.  Today we saw orange and black
butterflies (monarchs migrating?) and what looked like but is too early for
a swarm of fireflies (no light).  

response 377 of 475:

Apr 17 14:51 UTC 2004

New boxes.  They were in stacks with brown paper wrapping.  The neighbors who
were moving had bought a bunch to use somehow at their wedding.

Today I plan to bike an old 3-speed into Kiwanis, and then walk to the river
if it is not raining.  We will bring in the Japanese wordprocessor too.